Wellbutrin and Nicotine Patches

Each year, approximately 20 million of the 50 million smokers in the United States try to quit smoking, but only about 6 percent of those who try succeed in quitting in the long term.

If you have a wish to quit smoking but you cannot make a choice from a variety from nicotine-replacement therapies or other methods, then you should learn the following.

First of all, it should be mentioned that your affect or mood appears to exert potent effects on the motivation to use nicotine. It is known that among smokers, symptoms of nicotine dependence are correlated with the magnitude of affective symptoms of depression. Thus, smokers are more subjected to symptoms of affective disorders than nonsmokers. Persons with a negative affect are more likely to start smoking and less likely to be able to quit. These effects may be related to changes in dopaminergic activity in the brain. At this, antidepressants such as Wellbutrin or anxiolytics may therefore be efficacious cessation aids.

However, many people who try to give up smoking use not only drugs but also nicotine patches at the same time. Usually it does not cause any side effects but the researches which were carried out to determine the usefulness of bupropion (Wellbutrin) alone or with nicotine patches gave the following results.

Treatment with sustained-release bupropion alone or in combination with a nicotine patch resulted in significantly higher long-term rates of smoking cessation than use of nicotine patch alone. Abstinence rates were higher with combination therapy than with bupropion alone, but the difference was not statistically significant.

Another experiment was to determine whether long-term use of bupropion reduces the rate of relapse to smoking in smokers who stop smoking with nicotine patch therapy, and whether bupropion can initiate smoking abstinence among smokers who have failed to stop smoking after nicotine patch therapy.

The results showed that Bupropion did not reduce relapse to smoking in smokers who stopped smoking with nicotine patch therapy. Bupropion did not initiate abstinence among smokers who failed to stop smoking with nicotine patch therapy.

Thus, the choice of a quit-smoking therapy should depend on the reasons that made you start smoking and your health state. If you experience or you know you are subjected to mood swings or negative affect, then it is better for you to choose Wellbutrin, in other cases nicotine patches may be more effective. Mind that it is very important to check it up with your doctor before taking Wellbutrin or before combining it with nicotine patches.