Torsemide: Mechanism of Action

Torsemide refers to the group of loop diuretics aimed at preventing your body from absorbing too much salt as well as at getting rid of electrolytes. Its main action is to increase urinary excretion of sodium, potassium salts, chloride and water.

Torsemide is often preferred over other loop diuretics due to its high bioavailability. It is absorbed very quickly after peroral intake or intravenous (IV) administration. There is no significant difference between oral or IV administration in the magnitude of the diuretic response. However, following oral administration, the onset of diuresis occurs within 1 hour while following IV administration, the onset of diuresis occurs within 10 minutes. Normally the diuretic effect of Torsemide is lasting: it persists 6-8 hours after the drug's administration.

While taking Torsemide you will have to work out a dosing schedule for yourself. Since Torsemide will cause you to urinate more, do not use it at any time of the day when it can cause you troubles. For example, it is not recommended to take it at bedtime. The optimal recommendation is to take this medication at least 4 hours before you go to bed or earlier in the day.

Torsemide has a number of salutary effects usually associated with loop diuretics of prolonged action to which it belongs. As a diuretic Torsemide is principally used in the following indications: edema associated with heart failure, renal impairment, nephropathy and hepatic cirrhosis; pulmonary edema where rapid diuresis is required, and hypertension. Besides, it is considered to be capable of reducing the risk of the impaired cardial function development more effectively than Furosemide or any other diuretic of a short-term action.

Thus, Torsemide is used to treat many diabetes-related diseases, but it should be borne in mind that Torsemide may increase the amount of glucose in the blood of a patient with diabetes mellitus. That is why monitoring your blood sugar levels is essential.

Being a diuretic Torsemide sometimes causes low potassium levels - a medical condition known as hypokalaemia. Torsemide accelerates the removal of potassium from the body. It is of special note that excessive loss of potassium usually accompanies the state of diabetic ketoacidosis which manifests itself in urinary losses of potassium from polyuria and from kidney tubules. That is why it is very dangerous to take Torsemide if you are having the state of diabetic ketoacidosis as the action is amplified and thus can lead to serious consequences threatening your health and even life. In less dangerous conditions hypokalaemia caused by Torsemide can be avoided by taking a potassium supplement.

Torsemide does not have many contraindications, but some important things which may cause complications are hypersensitivity or allergy to sulfonylurea drugs and anuria which is a complete suppression of urine formation, often as a result of a kidney disorder. Sometimes your doctor may just need adjust your dose to get the most efficacious results from Torsemide therapy. That is why it is important to remember that you should have your blood tested regularly while you take Torsemide.

Besides, Torsemide can cause dehydration and a serious mineral loss. The alarming symptoms are muscle cramps, confusion, weakness, headache, dizziness, dry mouth or excessive thirst, nausea or vomiting, seizures and fainting.

Sometimes Torsemide causes hearing loss, either temporary or permanent. Usually it is an outcome of IV administration of Torsemide. The other possible side-effects are milder and basically pass away with time.